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TIN (version 1.4.1)

Transcriptome instability analysis

Description

The TIN package implements a set of tools for transcriptome instability analysis based on exon expression profiles. Deviating exon usage is studied in the context of splicing factors to analyse to what degree transcriptome instability is correlated to splicing factor expression. In the transcriptome instability correlation analysis, the data is compared to both random permutations of alternative splicing scores and expression of random gene sets.

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Version

Version

1.4.1

License

Artistic-2.0

Maintainer

Bjarne Johannessen

Last Published

February 15th, 2017

Functions in TIN (1.4.1)

geneSets

geneSets
sampleSetFirmaScores

sampleSetFirmaScores
probesetPermutations

Permutations of the samples at each probeset
geneAnnotation

geneAnnotation
correlationPlot

correlationPlot
scatterPlot

Scatterplot showing relative amounts of aberrant exon usage per sample
readGeneSummaries

Read gene-level expression summaries
firmaAnalysis

Read CEL files and perform FIRMA analysis
posNegCorrPlot

posNegCorrPlot
correlation

Calculates the correlation between sample-wise amounts of aberrant exon usage and splicing factor expression levels
splicingFactors

A list of 280 splicing factor genes
sampleSetGeneSummaries

sampleSetGeneSummaries
aberrantExonUsage

Calculations of relative aberrant exon usage amounts per sample (based on FIRMA scores)
geneSetCorrelation

Correlation between aberrant exon usage and expression levels for a number of gene sets.
clusterPlot

clusterPlot