Segmentation of single- and multi-track copy number data by
penalized least squares regression.
Description
Penalized least squares regression is applied to fit
piecewise constant curves to copy number data to locate genomic
regions of constant copy number. Procedures are available for
individual segmentation of each sample, joint segmentation of
several samples and joint segmentation of the two data tracks
from SNP-arrays. Several plotting functions are available for
visualization of the data and the segmentation results.