DRIMSeq package - Differential splicing and sQTL analyses with Dirichlet-multinomial model in RNA-Seq

DRIMSeq package provides two frameworks. One for the differential splicing analysis between different conditions and one for the sQTL analysis. Both are based on modeling counts of genomic features (i.e., transcripts, exons or exonic bins) with Dirichlet-multinomial distribution. The package also makes available functions for visualization and exploration of the data and results.

Installation

To install the latest development version, use the devtool package (available here)

devtools::install_github("markrobinsonuzh/DRIMSeq")

Vignette

The vignette contains all the instructions on how to use the DRIMSeq package for differential and sQTL analyses. It can be found in the "vignettes/DRIMSeq.pdf" file. After installation, the vignette can be accessed from the R console by typing

browseVignettes("DRIMSeq")

In order to run the examples from the vignette and the manual, you need to install two data packages PasillaTranscriptExpr and GeuvadisTranscriptExpr.