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TrialSize (version 1.3)

R functions in Chapter 3,4,6,7,9,10,11,12,14,15

Description

functions and examples in Sample Size Calculation in Clinical Research.

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Version

Install

install.packages('TrialSize')

Monthly Downloads

942

Version

1.3

License

GPL (>= 2.15.1)

Maintainer

Vicky Wu

Last Published

June 3rd, 2013

Functions in TrialSize (1.3)

CrossOver.ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities in Crossover Design

Propensity.Score.strata

Propensity Score with Stratas

QT.PK.parallel

Parallel Group Design in QT/QTc Studies with PK response as covariate

TwoSampleMean.NIS

Two Sample Mean Test for Non-Inferiority/Superiority

TwoSampleSeqCrossOver.NIS

Two sample proportion Crossover design for Non-inferiority/Superiority

OneSide.varyEffect

One-Sided Tests with varying effect sizes

QT.crossover

Crossover Design in QT/QTc Studies without covariates

MeanWilliamsDesign.Equality

Test for Equality in Multiple-Sample William Design

RelativeRiskCrossOver.NIS

Relative Risk in Crossover Design test for Non-inferiority/Superiority

TwoSide.varyEffect

Two-Sided Tests with varying effect sizes

OneSampleProportion.Equivalence

One sample proportion test for equivalence

TwoSampleProportion.NIS

Two sample proportion test for Non-Inferiority/Superiority

Cox.NIS

Test for non-inferiority/superiority in Cox PH model.

OneSampleMean.Equality

One Sample Mean Test for Equality

AB.withoutDescalation

A + B Escalation Design without Dose De-escalation

OneWayANOVA.pairwise

Pairwise Comparison for Multiple-Sample One-Way ANOVA

ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities

OneSide.fixEffect

One-Sided Tests with fixed effect sizes

QT.parallel

Parallel Group Design in QT/QTc Studies without covariates

TwoSampleProportion.Equality

Two sample proportion test for equality

Nonpara.Independ

Test for independence for nonparametric study

TwoSampleProportion.Equivalence

Two sample proportion test for equivalence

TwoSampleCrossOver.NIS

Two Sample Crossover Design Test for Non-Inferiority/Superiority

RelativeRiskCrossOver.Equality

Relative Risk in Crossover Design test for Equality

TrialSize-package

Sample Size calculation in Clinical Research

QT.PK.crossover

Crossover Design in QT/QTc Studies with PK response as covariate

WilliamsDesign.Equivalence

Williams Design test for equivalence

TwoSampleSurvival.NIS

Test for two sample Non-Inferiority/Superiority in exponential model for survival data

Nonpara.One.Sample

One Sample Location problem in Nonparametric

Vaccine.CEM

Composite Efficacy Measure(CEM) for Vaccine clinical trials.

WilliamsDesign.Equality

William Design test for equality

AB.withDescalation

A + B Escalation Design with Dose De-escalation

InterSV.Equality

Test for Equality of Inter-Subject Variabilities

RelativeRisk.Equivalence

Relative Risk in Parallel Design test for Equivalence

ISCV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject CVs

RelativeRisk.NIS

Relative Risk in Parallel Design test for Non-inferiority/Superiority

Vaccine.RDI

Reduction in Disease Incidence(RDI) for Vaccine clinical trials.

Vitro.BE

In Vitro Bioequivalence

OneSampleMean.NIS

One Sample Mean Test for Non-Inferiority/Superiority

gof.Pearson.twoway

Test Goodness of Fit by Pearson's Test for two-way table

OneSampleProportion.Equality

One sample proportion test for equality

Cochran.Armitage.Trend

Cochran-Armitage's Test for Trend

OneWayANOVA.PairwiseComparison

One-way ANOVA pairwise comparison

OneSampleProportion.NIS

One sample proportion test for Non-inferiority/Superiority

Cox.Equality

Test for equality in Cox PH model.

Dose.Min.Effect

Williams' Test for Minimum effective dose (MED)

RelativeRisk.Equality

Relative Risk in Parallel Design test for Equality

TwoSampleCrossOver.Equality

Two Sample Crossover Design Test for Equality

TwoSampleSurvival.Equivalence

Test for two sample equivalence in exponential model for survival data

OneSampleMean.Equivalence

One Sample Mean Test for Equivalence

TwoSampleCrossOver.Equivalence

Two Sample Crossover Design Test for Equivalence

Cox.Equivalence

Test for Equivalence in Cox PH model.

McNemar.Test

McNemar Test in 2 by 2 table

Nonpara.Two.Sample

Two sample location problem for Nonparametric

TwoSampleSurvival.Equality

Test for two sample equality in exponential model for survival data

Carry.Over

Test the Carry-over effect

Multiple.Testing

Multiple Testing procedures

Propensity.Score.nostrata

Propensity Score ignoring strata

TwoSampleSeqCrossOver.Equality

Two sample proportion Crossover design test for equality

Example.3.1.4

One Sample Mean Equality

InterSV.NIS

Test for Equality of Inter-Subject Variabilities

PBE

Population Bioequivalence

TwoSide.fixEffect

Two-Sided Tests with fixed effect sizes

ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilities

Sensitivity.Index

Calculate the power for Sensitivity Index

TwoSampleSeqCrossOver.Equivalence

Two sample proportion Crossover design test for equivalence

Vaccine.ELDI

The evaluation of vaccine efficacy with Extremely Low Disease Incidence(ELDI)

CrossOver.ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilitie in Crossover Design

ISCV.Equality

Test for Equality of Intra-Subject CVs

ANOVA.Repeat.Measure

ANOVA with Repeat Measures

gof.Pearson

Test Goodness of Fit by Pearson's Test

ABE

Average Bioequivalence

Stuart.Maxwell.Test

Stuart-Maxwell Test

Dose.Response.time.to.event

Linear Contrast Test for Time-to-Event Endpoint in dose response study

IBE

Individual Bioequivalence

Dose.Response.Linear

Linear Contrast Test for Dose Response Study

RelativeRiskCrossOver.Equivalence

Relative Risk in Crossover Design test for Equivalence

Dose.Response.binary

Linear Contrast Test for Binary Dose Response Study

TwoSampleSurvival.Conditional

Test for two sample conditional data in exponential model for survival data

ISV.Equality

Test for Equality of Intra-Subject Variabilities

TwoSampleMean.Equivalence

Two Sample Mean Test for Equivalence

MeanWilliamsDesign.NIS

Test for Non-Inferiority/Superiority in Multiple-Sample William Design

QOL

Quality of life

ISCV.Equivalence

Test for Equivalence of Intra-Subject CVs

MeanWilliamsDesign.Equivalence

Test for Equivalence in Multiple-Sample William Design

TwoSampleMean.Equality

Two Sample Mean Test for Equality

CrossOver.ISV.Equality

Test for Equality of Intra-Subject Variabilities in Crossover Design

WilliamsDesign.NIS

Williams Design test for Non-inferiority/Superiority