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PAC (version 1.1.6)

Partition-Assisted Clustering and Multiple Alignments of Networks

Description

Implements partition-assisted clustering and multiple alignments of networks. It 1) utilizes partition-assisted clustering to find robust and accurate clusters and 2) discovers coherent relationships of clusters across multiple samples. It is particularly useful for analyzing single-cell data set. Please see Li et al. (2017) for detail method description.

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Version

Install

install.packages('PAC')

Monthly Downloads

239

Version

1.1.6

License

GPL-3

Maintainer

Ye Li

Last Published

December 15th, 2025

Functions in PAC (1.1.6)

JaccardSM

Calculates the Jaccard similarity matrix.
annotateClades

Creates annotation matrix for the clades in aggregated format. The matrix contains average signals of each dimension for each clade in each sample
getAverageSpreadOf2SubpopClades

Calculate the (global) average spread of subpopulations in clades with 2 subpopulations on the constellation plot.
getExtraneousCladeSubpopulations

Calculates subpopulations in clades (with two or more subpopulations) that are too far away from other subpopulations (within the same clade) on the constellation plot; these far away subpopulations should be pruned away from the original clades.
BSPLeaveCenter

Finds N Leaf centers in the data
samplePass

Run PAC for Specified Samples
MINetworkPlot_topEdges

Plots mutual information network (mrnet algorithm) connection using the parmigene package. Mutual information calculated with infotheo package.
MAN

Creates network alignments using network constructed from subpopulations after PAC
constellationPlot

Makes constellation plot, in which the centroids are clusters are embedded in the t-SNE 2D plane and the cross-sample relationships are plotted as lines connecting related sample clusters (clades).
refineSubpopulationLabels

Refines the subpopulation labels from PAC using network alignment and small subpopulation information. Outputs a new set of files containing the representative labels.
recordWithinClusterSpread

Calculates the within cluster spread
renamePrunedSubpopulations

Prune away specified subpopulations in clades that are far away.
runElbowPointAnalysis

Runs elbow point analysis to find the practical optimal number of clades to output. Outputs the average within sample cluster spread for all samples and the elbow point analysis plot with loess line fitted through the results.
fmeasure

F-measure Calculation
getRepresentativeNetworks

Representative Networks
PAC

Partition Assisted Clustering PAC 1) utilizes dsp or bsp-ll to recursively partition the data space and 2) applies a short round of kmeans style postprocessing to efficiently output clustered labels of data points.
outputNetworks_topEdges_matrix

Wrapper to output the mutual information networks for subpopulations with size larger than a desired threshold.
MINetwork_simplified_topEdges

Outputs the vectorized summary of a network based on the number of edges connected to a node
MINetwork_matrix_topEdges

Mutual information network connection matrix generation (mrnet algorithm) using the parmigene package. Mutual information calculated with infotheo package.
heatmapInput

Creates the matrix that can be easily plotted with a heatmap function available in an R package
aggregateData

Aggregates results from the clustering and merging step.
outputRepresentativeNetworks_topEdges

Outputs the representative/clade networks (plots and summary vectors) for subpopulations with size larger than a desired threshold. Saves the networks and the data matrices without the smaller subpopulations.
annotationMatrix_withSubpopProp

Adds subpopulation proportion for the annotation matrix for the clades