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SMITE (version 1.0.2)

Significance-based Modules Integrating the Transcriptome and Epigenome

Description

This package builds on the Epimods framework which facilitates finding weighted subnetworks ("modules") on Illumina Infinium 27k arrays using the SpinGlass algorithm, as implemented in the iGraph package. We have created a class of gene centric annotations associated with p-values and effect sizes and scores from any researchers prior statistical results to find functional modules.

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Version

Version

1.0.2

License

GPL (>=2)

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Maintainer

Neil Ari Wijetunga

Last Published

February 15th, 2017

Functions in SMITE (1.0.2)

addShadowText

Add shadow text (a second color bordering the text) to a plot
SMITE-package

Significance-based Modules Integrating the Transcriptome and Epigenome
plotCompareScores

Compare two genomic features by score and display them in a hexbin plot
annotateModification

Adding modification data to a PvalueAnnotation
extractScores

Extract scores for all genes
methylationdata

A toy dataset of DNA methylation to test within SMITE
extractModules

View specific modules within a PvalueAnnotation
convertGeneIds

Convert between gene ids
Reactome.Symbol.Igraph

An Igraph network for REACTOME with nodes as gene symbols
extractGOseq

View the GOseq pathway analysis after having run Goseq, or search for a term.
extractExpression

View the expression data stored in a PvalueAnnotation
genes_for_conversiontest

A small set of RefSeq genes for converting
hg19_genes_bed

A bed file annotating Refseq genes for the hg19 genome build
histone_h3k4me1

A toy dataset of H3k4me1 peaks to test within SMITE
plotDensityPval

Plot the density of the combined scores stored in a PvalueObject
normalizePval

This function normalizes p-values (Scores) that are otherwise on different scales.
test_annotation_score_data

A toy PvalueAnnotation
makePvalueAnnotation

Initialize a PvalueAnnotation
highScores

Generate a vector of the highest scoring genes
runBioNet

Perform BioNet Analysis on a PvalueAnnotation
removeModification

A function to "unload" a modification that has already been added.
makePvalueObject

Function to make a PvalueObject within a PvalueAnnotation
curated_expressiondata

A toy dataset ofcurated RNA-seq to test within SMITE
plotModule

Plot a specific module after running Spinglass algorithm
scorePval

Making a single combined score for each gene
runGOseq

Run a GoSeq pathway analysis
extractModification

Extract some or all loaded modifications or a the summary of combined effects
runSpinglass

Run Spinglass algorithm on a Scored PvalueAnnotation
stoufferTest

Stouffer's Test
annotateExpression

Adding expression data to a PvalueAnnotation