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genomation (version 1.4.2)

Summary, annotation and visualization of genomic data

Description

A package for summary and annotation of genomic intervals. Users can visualize and quantify genomic intervals over pre-defined functional regions, such as promoters, exons, introns, etc. The genomic intervals represent regions with a defined chromosome position, which may be associated with a score, such as aligned reads from HT-seq experiments, TF binding sites, methylation scores, etc. The package can use any tabular genomic feature data as long as it has minimal information on the locations of genomic intervals. In addition, It can use BAM or BigWig files as input.

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Version

Version

1.4.2

License

Artistic-2.0

Maintainer

Altuna Akalin

Last Published

February 15th, 2017

Functions in genomation (1.4.2)

convertBedDf

convert a data frame read-in from a bed file to a GRanges object
genes

Example RefSeq genes data set.
convertBed2Exons

convert a data frame read-in from a bed file to a GRanges object for exons
annotateWithFeatureFlank

Function to annotate a given GRanges object with promoter,exon,intron & intergenic values
plotGeneAnnotation

Plots the enrichment of each feature in the set in the gene annotation
calculateOverlapSignificance

function that calculates the significance of overlaps of two sets of features using randomization
ScoreMatrixList

Make ScoreMatrixList from multiple targets
getAssociationWithTSS

Get distance to nearest TSS and gene id from AnnotationByGeneParts
show,RandomEnrichment-method

show method for some of the genomation classes
plotMeta

Line plot(s) for meta-region profiles
getMembers

Get the membership slot of AnnotationByFeature
ScoreMatrix-class

An S4 class for storing ScoreMatrix function results
scaleScoreMatrix

Scales the values in the matrix by rows and/or columns
Ops,ScoreMatrixList,numeric-method

Ops method for a ScoreMatrixList object. It enables to use arithmetic, indicator and logic operations on ScoreMatrixList objects.
readBroadPeak

A function to read the Encode formatted broad peak file into a GRanges object
Ops,ScoreMatrixList,ScoreMatrixList-method

Ops method for a ScoreMatrixList object. It enables to use arithmetic, indicator and logic operations on ScoreMatrixList objects.
convertBed2Introns

convert a data frame read-in from a bed file to a GRanges object for introns
heatMeta

Heatmap for meta-region profiles
annotateWithGeneParts

Annotate given object with promoter, exon, intron and intergenic regions
[,ScoreMatrixList,ANY,ANY-method

Subsetting method for a ScoreMatrixList object
patternMatrix

Get scores that correspond to k-mer or PWM matrix occurrence for bases in each window
readFeatureFlank

A function to read-in genomic features and their upstream and downstream adjecent regions such as CpG islands and their shores
readGeneric

Read a tabular file and convert it to GRanges.
ScoreMatrix

Get base-pair score for bases in each window
RandomEnrichment-class

An S4 class for storing getRandomEnrichment function results
annotateWithFeature

Function to annotate given GRanges object with a given genomic feature
readNarrowPeak

A function to read the Encode formatted narrowPeak file into a GRanges object
getFeatsWithTargetsStats

Get the percentage/count of annotation features overlapping with target features from AnnotationByFeature
getFlanks

Function to get upstream and downstream adjecent regions to a genomic feature such as CpG islands
readTranscriptFeatures

Function for reading exon intron and promoter structure from a given bed file
AnnotationByGeneParts-class

An S4 class that information on overlap of target features with annotation features
Ops,numeric,ScoreMatrixList-method

Ops method for a ScoreMatrixList object. It enables to use arithmetic, indicator and logic operations on ScoreMatrixList objects.
getRandomEnrichment

get enrichment based on randomized feature overlap
intersectScoreMatrixList

Get common rows from all matrices in a ScoreMatrixList object
heatMatrix

Draw a heatmap of a given ScoreMatrix object
orderBy

Reorder all elements of a ScoreMatrixList to a given ordering vector
scaleScoreMatrixList

Scale the ScoreMatrixList
cpgi

Example CpG island data set.
cage

Example CAGE data set.
ScoreMatrixList-class

An S4 class for storing a set of ScoreMatrixList
getTargetAnnotationStats

Get the percentage of target features overlapping with annotation from AnnotationByFeature
gffToGRanges

Converts a gff formated data.frame into a GenomicRanges object. The GenomicRanges object needs to be properly formated for the function to work.
randomizeFeature

function that randomizes the genomic coordinates
AnnotationByFeature-class

An S4 class that information on overlap of target features with annotation features
readBed

Read a BED file and convert it to GRanges.
Ops,ScoreMatrix,ScoreMatrix-method

Ops method for a ScoreMatrix object. It enables to use arithmetic, indicator and logic operations on ScoreMatrix objects.
ScoreMatrixBin

Get bin score for bins on each window
binMatrix

Bins the columns of a matrix using a user provided function
findFeatureComb

Find combitations of genomic features
multiHeatMatrix

Draw multiple heatmaps from a ScoreMatrixList object
[,ScoreMatrix,ANY,ANY-method

Subsetting method for a ScoreMatrix object.
plotTargetAnnotation

Plot annotation categories from AnnotationByGeneParts or AnnotationByFeature
promoters

Example promoter data set.